Hemopexin increases the neurotoxicity of hemoglobin when haptoglobin is absent
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چکیده
منابع مشابه
Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders
The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). Because heme toxicity is the impetus for much of the pathology in sepsis, sickl...
متن کاملAssociation between haptoglobin, hemopexin and mortality in adults with sepsis
INTRODUCTION Plasma levels of cell-free hemoglobin are associated with mortality in patients with sepsis; however descriptions of independent associations with free hemoglobin and free heme scavengers, haptoglobin and hemopexin, are lacking beyond their description as acute phase reactants. We sought to determine the association of plasma levels of endogenous free hemoglobin and haptoglobin and...
متن کاملHaptoglobin and Hemopexin in Heme Detoxification and Iron Recycling
The acute phase reaction is an early response aimed at the defence of the organism and at the re-establishment of homeostasis in response to acute infection, inflammation and other pathological states (Kushner, 1982). The putative mechanism responsible for this reaction is based on an initial signal derived from macrophages and other cells that synthesize and secrete several factors (probably c...
متن کاملInteraction between hemoglobin subunits in the hemoglobin . haptoglobin complex.
The accessibility of hemoglobin sulfhydryl groups to modification by p-mercuribenzoate @"B) was tested in order to investigate the effect of the hemoglobinhaptoglobin association on the contact between a and /3 chain subunits. Previous evidence indicates that a molecule of tetrameric hemoglobin binds to haptoglobin as two separate a& dimers. Modification of the hemoglobin a and B chain sullhydr...
متن کاملMolecular Modeling of the Human Hemoglobin-Haptoglobin Complex Sheds Light on the Protective Mechanisms of Haptoglobin
Hemoglobin (Hb) plays a critical role in human physiological function by transporting O2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp complex is subjected to CD163-mediated endocytosis by macrophages. The interaction between Hb and Hp is...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2018
ISSN: 0022-3042
DOI: 10.1111/jnc.14328